Interrelation of Immune, Antioxidant and Hormonal System Indices and their Influence on Melanogenesis in Patients with Skin Hyper Pigmentation

According to the results obtained after immunologic, hormonal and biochemical status investigations has been discussed peculiarities of melanogenesis in 135 patients with skin hyper pigmentation (78 patients with pigmented nevus and 57 – with melasma). The average age consisted – 36,5 year. Of 135 patients 32 were men and 103 women. Patients with pigmented nevus revealed increased rate of CD4, CD25, CD69, HLA-DR, IL-1, IL-6, IL-8, ACTH, MSH, DC, MDA, SOD, GP, CL and decrease in CD3, CD8, CD16, CD95, IL-2, cortisol levels. In the group of patients with melasma increased level of CD20, CD25, HLA-DR+, MSH, ACTH, DC, MDA and reduced concentration of CD3+, CD4+, CD8+, CD16+, CD69+, CD95+, IL-1, cortisol, SOD and CL were registered. Comparison of component levels of LP-AP systems and suppressive (CD8) activity of lymphocytes in patients with hyper pigmentation revealed significant negative correlation and presence of close positive relation between CD25 and CD95 cells and indices of LP-AP systems and pituitary-adrenal gland systems as well. Has been detected positive correlation between IL-1 and cortisol in patients with melasma and negative correlation in patients with pigmented nevus. Patients with pigmented nevus revealed decreased production of IL-2 and on this background reduced concentration of cortisol was registered. In case of hyper pigmentation increased level of CD95 cells resulted in suppression of apoptosis and supported increase in quantity of melanocytes. Consequently, in case of hyper pigmentation insufficiency of apoptosis was obvious.Thus, in case of hyper pigmentation, interrelation of indices and intercellular regulations of immunologic, hormonal and antioxidant systems exists.